Review of Existing PRP Science

Christopher Allan Webb, PA-C, Platelet-Rich Plasma Update: Clinical Use in Musculoskeletal Care, Journal of Musculoskeletal Medicine, 2012;29:96-101, mixed reviews, a number of positive studies but more are needed.

Marx RE, Platelet-rich plasma: evidence to support its use, Journal of Oral and Maxillofacial Surgery 2004 62 (4): 489–96. doi:10.1016/j.joms.2003.12.003. PMID 15085519 dentistry, 10x concentrate best, shows Harvest machine produces highest concentration

Randomized/Blind/Controlled PRP Trials

Mishra AK, MD et al., Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients With Tennis Elbow, A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients, presented at the American Association of Orthopedic Surgeons
(AAOS) in Chicago, Mar. 21, 2013
, Tendon: Tennis Elbow; 71% improvement at 24 months

Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T, Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up, American Journal of Sports Medicine, 2010;38:255-262, Tendon: (Chronic Lateral) Epicondylitis; 73% lasting success w PRP

Vogrin M, Rupreht M, Crnjac A, et al., The effect of platelet-derived growth factors on knee stability after anterior cruciate ligament reconstruction: a prospective randomized clinical study, Wien Klin Wochenschr. 2010;122(suppl 2):91-95, ACL; significantly better knee stability with PRP

Wassim Raffoul, PD, Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing, Identifier: NCT00856934, January/February 2009, Wound healing; PRP + keratinocytes dramatically reduces healing times (50%) and pain (80-95%) if sprayed on wound dressings is one of the formal government databases, sponsored by the National Institute of Health.  At the time of this writing in 2013, 109 PRP trials were listed, 36 if which were completed, with 10 of them not quite relevant to PRP, for a total of 26 trials with results, as follows.
  • Most trials found that PRP reduces pain, at least in the short term. Some found that it greatly diminishes the rate of re-tears and probably strengthens structural integrity.
  • Two trials found that PRP helps collagen generation in skin and also helps diminish nasolabial folds
  • One trial found significant pain reduction and cure in chronic (tennis) elbow tendinosis
  • One trial found faster return to activity after Achilles tendon tear repairs (where PRP was used in addition to a surgery procedure
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